ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 1.1.1.106 is Orphan !
Common name :Pantoate 4-dehydrogenase

Systematic name :(R)-pantoate:NAD(+) 4-oxidoreductase

Other names :D-pantoate:NAD(+) 4-oxidoreductase
Pantoate dehydrogenase
Pantothenase
Panthothenase
Comments :The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form (2). No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3-alpha-hydroxysteroids (2). The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315). Also active with 3-alpha-hydroxysteroids.

Created :EC 1.1.1.106 created 1972, modified 1976

KEGG MAP : 00770 Pantothenate and CoA biosynthesis

BRENDA organisms :Pseudomonas fluorescens
Pseudomonas sp.

Swiss-ProtNo protein sequences are associated with EC 1.1.1.106 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 1.1.1.106 in TrEMBL

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for EC 1.1.1.106.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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