ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
   year of creation
EC used by the NC-IUBMBSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
   year of creation

Search by   NC-IUBMB EC number
   Enzyme name

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EC is Orphan !
Common name :Alcohol dehydrogenase (quinone)

Systematic name :Alcohol:quinone oxidoreductase

Other names :PQQ alcohol dehydrogenase
PQQ-dependent ADH
PQQ-dependent alcohol dehydrogenase
Pyrroloquinoline quinone-dependent alcohol dehydrogenase
Quinoprotein ADH
Quinoprotein alcohol dehydrogenase
Membrane associated quinohemoprotein alcohol dehydrogenase
Cofactors : Pyrroloquinoline quinone.

Comments :Only described in acetic acid bacteria where it is involved in acetic acid production. Associated with membrane. Electron acceptor is membrane ubiquinone. A model structure suggests that, like all other quinoprotein alcohol dehydrogenases, the catalytic subunit has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ; the catalytic subunit also has a heme c in the C-terminal domain. The enzyme has two additional subunits, one of which contains three molecules of heme c. It does not require amines for activation. It has a restricted substrate specificity, oxidizing a few primary alcohols (C2 to C6), but not methanol, secondary alcohols and some aldehydes. It is assayed with phenazine methosulfate or with ferricyanide.

Created :EC created 2009, modified 2010

BRENDA organisms :Acetobacter aceti
Acetobacter pasteurianus
Acetobacter pasteurianus
Acetobacter sp.
Acidomonas methanolica
Gluconacetobacter diazotrophicus
Gluconacetobacter europaeus
Gluconacetobacter europaeus
Gluconacetobacter intermedius
Gluconacetobacter polyoxogenes
Gluconacetobacter xylinus
Gluconobacter oxydans
Gluconobacter sp.

Swiss-ProtNo protein sequences are associated with EC in Swiss-Prot

TrEMBLNo protein sequences are associated with EC in TrEMBL

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