ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 1.13.12.17 is Orphan !
Common name :Dichloroarcyriaflavin A synthase

Systematic name :Dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming)

Other names :Nitroalkane oxidase
2-NPD
NMO
Comments :The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P(450) oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold (1). Along with RebC, a flavin-dependent hydroxylase, it also catalyzes the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A (2). The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine (3). The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P(450) oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold. Along with RebC, a flavin-dependent hydroxylase, it also catalyzes the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine.

Created :EC 1.13.12.17 created 2010

BRENDA organisms :Streptomyces albus
Streptomyces longisporoflavus
Streptomyces longisporoflavus
Streptomyces sp.
Prosite :PDOC00081

Swiss-ProtNo protein sequences are associated with EC 1.13.12.17 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 1.13.12.17 in TrEMBL

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for EC 1.13.12.17.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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