ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 1.14.13.108 is Orphan !
Common name :Abieta-7,13-diene hydroxylase

Systematic name :Abieta-7,13-diene,NADPH:oxygen oxidoreductase (18-hydroxylating)

Other names :CYP170A1
Cofactors : Heme-thiolate.

Comments :A heme-thiolate protein (P-450). This enzyme catalyzes a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase (1). Activity is induced by wounding of the plant tissue (2). This enzyme catalyzes a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). Activity is induced by wounding of the plant tissue.

Created :EC 1.14.13.108 created 2009, modified 2012

KEGG MAP : 01100 Metabolic pathways
01110 Biosynthesis of secondary metabolites
00904 Diterpenoid biosynthesis

BRENDA organisms :Abies grandis
Pinus contorta

Swiss-ProtNo protein sequences are associated with EC 1.14.13.108 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 1.14.13.108 in TrEMBL

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for EC 1.14.13.108.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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