ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 1.14.13.111 is Orphan !
Common name :Methanesulfonate monooxygenase

Systematic name :Methanesulfonate,NADH:oxygen oxidoreductase

Other names :Mesylate monooxygenase
Mesylate,reduced-FMN:oxygen oxidoreductase
MsmABC
Methanesulfonic acid monooxygenase
MSA monooxygenase
MSAMO
Cofactors : Flavoprotein; Iron-sulfur.

Comments :A flavoprotein. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, alkanesulfonate monooxygenase, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules, such as arylsulfonates and aromatic sulfonates (1). The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising an hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] center. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methane- to butanesulfonate) and excludes all larger molecules, such as arylsulfonates and aromatic sulfonates. The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising an hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] center. Formerly EC 1.14.14.6.

Created :EC 1.14.13.111 created 2009 as EC 1.14.14.6, transferred 2010 to EC 1.14.13.111

KEGG MAP : 00920 Sulfur metabolism

BRENDA organisms :Afipia felis
Marinosulfonomonas methylotropha
Methylosulfonomonas methylovora

Swiss-ProtNo protein sequences are associated with EC 1.14.13.111 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 1.14.13.111 in TrEMBL

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for EC 1.14.13.111.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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