ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC used by the NC-IUBMBSorted by :
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EC 1.17.99.4 is Orphan !
Common name :Uracil/thymine dehydrogenase

Systematic name :Uracil:acceptor oxidoreductase

Other names :Uracil oxidase
Uracil-thymine oxidase
Uracil dehydrogenase
Comments :Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 (dihydrouracil dehydrogenase (NAD(+))) or EC 1.3.1.2 (dihydropyrimidine dehydrogenase (NADP(+))), EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (beta-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH(3) and CO(2) (5). Formerly EC 1.2.99.1. Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 and EC 3.5.1.95. Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 or EC 1.3.1.2, EC 3.5.2.2 and EC 3.5.1.6, with the ultimate degradation products being an L-amino acid, NH(3) and CO(2). Formerly EC 1.1.99.19 and EC 1.2.99.1.

Created :EC 1.17.99.3 created 2005

KEGG MAP : 00240 Pyrimidine metabolism

BRENDA organisms :Aerobic soil
Corynebacterium sp.
Enterobacter aerogenes
Mycobacterium sp.
Rhodococcus erythropolis

Swiss-ProtNo protein sequences are associated with EC 1.17.99.4 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 1.17.99.4 in TrEMBL

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for EC 1.17.99.4.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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