ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 1.3.99.8 is Orphan !
Common name :2-furoyl-CoA dehydrogenase

Systematic name :2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)

Other names :2-furoyl coenzyme A dehydrogenase
2-furoyl coenzyme A hydroxylase
Furoyl-CoA hydroxylase
2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)
Cofactors : Copper.

Comments :A copper protein. The oxygen atom of the -OH produced is derived from water, not O(2); the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH(2)- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH(2)-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors. The oxygen atom of the -OH produced is derived from water, not O(2). The actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH(2)- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH(2)-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.

Created :EC 1.3.99.8 created 1976

KEGG MAP : 00365 Furfural degradation

BRENDA organisms :Pseudomonas putida

Swiss-ProtNo protein sequences are associated with EC 1.3.99.8 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 1.3.99.8 in TrEMBL

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for EC 1.3.99.8.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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