ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
   year of creation
   organism
EC used by the NC-IUBMBSorted by :
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   classes of activity
   KEGG metabolism pathway
   year of creation

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EC 2.4.99.20 is Orphan !
Common name :2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

Systematic name :NADP(+):nicotinate ADP-ribosyltransferase

Other names :CD38 (gene name)
BST1 (gene name)
Comments :This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyzes EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyzes EC 3.2.2.6.

Created :EC 2.4.99.20 created 2014

KEGG MAP : 00760 Nicotinate and nicotinamide metabolism

BRENDA organisms :null

Swiss-ProtNo protein sequences are associated with EC 2.4.99.20 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 2.4.99.20 in TrEMBL

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for EC 2.4.99.20.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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