ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 2.7.7.67 is Orphan !
Common name :CDP-archaeol synthase

Systematic name :CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase

Other names :CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase
CTP:2,3-GG-GP ether cytidylyltransferase
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase
Cofactors : Magnesium; Potassium.

Comments :This enzyme catalyzes one of the steps in the biosynthesis of polar lipids in Archaea, which are characterized by having an sn-glycero-1-phosphate backbone rather than an sn-glycero-3-phosphate backbone as is found in bacteria and eukaryotes (1). The enzyme requires Mg(2+) and K(+) for maximal activity (1). The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase) and EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase), which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by this enzyme to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine (1). Catalyzes one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycero-1-phosphate backbone rather than an sn-glycero-3-phosphate backbone as is found in bacteria and eukaryotes. The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by this enzyme to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine. Formerly EC 2.7.7.n2.

Created :EC 2.7.7.67 created 2009

KEGG MAP : 00564 Glycerophospholipid metabolism

BRENDA organisms :Methanothermobacter thermautotrophicus

Swiss-ProtNo protein sequences are associated with EC 2.7.7.67 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 2.7.7.67 in TrEMBL

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Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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