ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 3.4.15.4 is Orphan !
Common name :Peptidyl-dipeptidase B

Systematic name :-

Other names :Atrial di-(tri)peptidyl carboxyhydrolase
Atrial dipeptidyl carboxyhydrolase
Atrial peptide convertase
Atriopeptin convertase
Dipeptidyl carboxyhydrolase
Peptidyldipeptidase B
Atrial di-(tri-)peptidyl carboxylase
Cofactors : Zinc.

Comments :A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl(-) dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II. A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to EC 3.4.15.1 it displays no chlorine dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase a is unable to release Phe-Arg from the C-terminus of atriopeptin II.

Created :EC 3.4.15.4 created 1992

BRENDA organisms :Bos taurus

Swiss-ProtNo protein sequences are associated with EC 3.4.15.4 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 3.4.15.4 in TrEMBL

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for EC 3.4.15.4.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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