ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
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EC used by the NC-IUBMBSorted by :
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   classes of activity
   KEGG metabolism pathway
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EC 3.4.24.60 is Orphan !
Common name :Dactylysin

Systematic name :-

Other names :PHIE
Peptide hormone inactivating endopeptidase
Comments :An endopeptidase of 100 kDa secreted from the skin of the amphibian, Xenopus laevis (Dactyletre du Cap). Resembles neprilysin in insensitivity to 1 mu-M captopril, but differs from it in being insensitive to thiorphan (1 mu-M) and unable to digest (Met(5))enkephalin, (Leu(5))enkephalin, oxytocin, and substance P-(7-11)-peptide. A similar endopeptidase is found in human neuroblastoma cells (2). An endopeptidase of 100 kDa secreted from the skin of Xenopus laevis. Resembles neprilysin in insensitivity to 1 uM captopril, but differs in being insensitive to thiorphan and unable to digest (5-Met)-enkephalin, (5-Leu)-enkephalin, oxytocin and substance P-(7-11)-peptide.

Created :EC 3.4.24.60 created 1995

BRENDA organisms :Homo sapiens
Xenopus laevis

Swiss-ProtNo protein sequences are associated with EC 3.4.24.60 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 3.4.24.60 in TrEMBL

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for EC 3.4.24.60.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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