ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 4.1.2.32 is Orphan !
Common name :Trimethylamine-oxide aldolase

Systematic name :Trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)

Other names :Trimethylamine N-oxide aldolase
Trimethylamine N-oxide demethylase
Trimethylamine N-oxide formaldehyde-lyase
Trimethylamine-N-oxide formaldehyde-lyase
Comments :A microsomal hemeprotein that catalyzes two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.99.9), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17-alpha-hydroxyprogesterone and 17-alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter (2). A microsomal hemeprotein that catalyzes two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.99.9), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17-alpha-hydroxyprogesterone and 17-alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter.

Created :EC 4.1.2.32 created 1978

KEGG MAP : 01120 Microbial metabolism in diverse environments
00680 Methane metabolism

BRENDA organisms :Aminobacter aminovorans
Bacillus sp.
Brosme brosme
Dosidicus gigas
Gadus morhua
Lota lota
Melanogrammus aeglefinus
Merlangius merlangus
Molva dipterygia
Molva molva
Pollachius pollachius
Pollachius virens
Urophycis chuss

Swiss-ProtNo protein sequences are associated with EC 4.1.2.32 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 4.1.2.32 in TrEMBL

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Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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