ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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   classes of activity
   KEGG metabolism pathway
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EC used by the NC-IUBMBSorted by :
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   classes of activity
   KEGG metabolism pathway
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EC 4.2.1.111 is Orphan !
Common name :1,5-anhydro-D-fructose dehydratase

Systematic name :1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming)

Other names :1,5-anhydro-D-fructose 4-dehydratase
1,5-anhydro-D-fructose hydrolyase
1,5-anhydro-D-arabino-hex-2-ulose dehydratase
AFDH
AF dehydratase
1,5-anhydro-D-fructose hydro-lyase
Cofactors : Calcium or sodium or magnesium.

Comments :This enzyme catalyzes one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose (1,2). The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.2.13 (exo-(1->4)-alpha-D-glucan lyase) and EC 5.3.2.7 (ascopyrone tautomerase). Requires divalent (Ca(2+) or Mg(2+)) or monovalent cations (Na(+)) for optimal activity. Unlike EC 4.2.1.110, aldos-2-ulose dehydratase, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity toward aldose-2-uloses such as 2-dehydroglucose (1,2,3). In addition, it is inhibited by its end-product ascopyrone M (2) and it cannot convert the end-product ascopyrone M into microthecin, as can EC 4.2.1.110. Catalyzes one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose. The other enzymes involved in this pathway are EC 4.2.1.110, EC 4.2.2.13 and EC 5.3.2.7. Unlike EC 4.2.1.110 the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity toward aldose-2-uloses such as 2-dehydroglucose; in addition, it is inhibited by its end-product ascopyrone M and it cannot convert the end-product ascopyrone M into microthecin, as can EC 4.2.1.110.

Created :EC 4.2.1.111 created 2006

BRENDA organisms :Anthracobia melaloma
Anthracobia melanoma
Peziza petersii
Plicaria anthracina
Plicaria leiocarpa

Swiss-ProtNo protein sequences are associated with EC 4.2.1.111 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 4.2.1.111 in TrEMBL

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for EC 4.2.1.111.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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