ORENZA : a database of ORphan ENZyme Activities

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EC 4.2.1.117 is Orphan !
Common name :2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)

Systematic name :(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate forming)

Other names :FlaA1
UDP-N-acetylglucosamine hydro-lyase (inverting
UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose-forming)
UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase
PseB
Cofactors : Iron-sulfur.

Comments :Catalyzes the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates (1). An iron-sulfur protein. Catalyzes the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propanoate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates.

Created :EC 4.2.1.117 created 2009

BRENDA organisms :Shewanella oneidensis

Swiss-ProtNo protein sequences are associated with EC 4.2.1.117 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 4.2.1.117 in TrEMBL

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for EC 4.2.1.117.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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