ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
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EC 4.2.1.65 is Orphan !
Common name :3-cyanoalanine hydratase

Systematic name :L-asparagine hydro-lyase (3-cyanoalanine-forming)

Other names :Beta-CNA nitrilase
Beta-CNAla hydrolase
Beta-cyanoalanine hydrolase
Beta-cyanoalanine hydratase
L-asparagine hydro-lyase
Comments :This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyzes EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyze all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates (4). This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyzes EC 5.3.3.14. Despite the differences both forms can catalyze all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates. Formerly EC 4.2.1.58, EC 4.2.1.60 and EC 4.2.1.61.

Created :EC 4.2.1.65 created 1976

KEGG MAP : 01100 Metabolic pathways
00460 Cyanoamino acid metabolism

BRENDA organisms :Bacillus megaterium
Lupinus angustifolius
Lupinus angustifolius
Pseudomonas sp.
Sorghum bicolor

Swiss-ProtNo protein sequences are associated with EC 4.2.1.65 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 4.2.1.65 in TrEMBL

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for EC 4.2.1.65.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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