ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
   year of creation
   organism
EC used by the NC-IUBMBSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
   year of creation

Search by   NC-IUBMB EC number
   Enzyme name
   Species



ORENZA   Home Page
   About Orenza

   Download
   Report Sequence Evidence


EC 5.2.1.10 is Orphan !
Common name :2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase

Systematic name :2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase

Other names :2-chlorocarboxymethylenebutenolide isomerase
Chlorodienelactone isomerase
Comments :The first type of this enzyme found (1) proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively. The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

Created :EC 5.2.1.10 created 1992

KEGG MAP : 01100 Metabolic pathways
01120 Microbial metabolism in diverse environments
00361 Chlorocyclohexane and chlorobenzene degradation

BRENDA organisms :Pseudomonas sp.

Swiss-ProtNo protein sequences are associated with EC 5.2.1.10 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 5.2.1.10 in TrEMBL

Click here to Report Sequence Evidence
for EC 5.2.1.10.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

 Contact us / © orenza 2012