ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
   year of creation
   organism
EC used by the NC-IUBMBSorted by :
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   classes of activity
   KEGG metabolism pathway
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EC 5.2.1.9 is Orphan !
Common name :Farnesol 2-isomerase

Systematic name :(2E,6E)-farnesol 2-cis-trans-isomerase

Other names :Farnesol isomerase
Comments :The first type of this enzyme found (1) proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively. The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

Created :EC 5.2.1.9 created 1989

KEGG MAP : 00909 Sesquiterpenoid and triterpenoid biosynthesis
01110 Biosynthesis of secondary metabolites

BRENDA organisms :Andrographis paniculata

Swiss-ProtNo protein sequences are associated with EC 5.2.1.9 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 5.2.1.9 in TrEMBL

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for EC 5.2.1.9.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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