ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
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EC used by the NC-IUBMBSorted by :
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   classes of activity
   KEGG metabolism pathway
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EC 6.2.1.10 is Orphan !
Common name :Acid--CoA ligase (GDP-forming)

Systematic name :Carboxylic acid:CoA ligase (GDP-forming)

Other names :Acyl coenzyme A synthetase (guanosine diphosphate forming)
Acyl-CoA synthetase (GDP-forming)
Comments :Requires Mg(2+) for activity. This membrane-bound enzyme catalyzes the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. The second step involves EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase and converts the acyl-CoA thioester into the corresponding N-acyl amidate by conjugation with glycine or taurine (5). Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates (6). This membrane-bound enzyme catalyzes the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. The second step involves EC 2.3.1.65 and converts the acyl-CoA thioester into the corresponding N-acyl amidate by conjugation with glycine or taurine. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates. Formerly EC 6.2.1.29.

Created :EC 6.2.1.10 created 1972, modified 2011

BRENDA organisms :Rattus norvegicus

Swiss-ProtNo protein sequences are associated with EC 6.2.1.10 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 6.2.1.10 in TrEMBL

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for EC 6.2.1.10.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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