ORENZA : a database of ORphan ENZyme Activities

ORphan ENZyme ActivitiesSorted by :
   EC number
   classes of activity
   KEGG metabolism pathway
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EC used by the NC-IUBMBSorted by :
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   classes of activity
   KEGG metabolism pathway
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EC 6.3.2.14 is Orphan !
Common name :Enterobactin synthase

Systematic name :2,3-dihydroxybenzoate:L-serine ligase

Other names :2,3-dihydroxybenzoylserine synthetase
N-(2,3-dihydroxybenzoyl)-serine synthetase
2,3-dihydroxybenzoate--serine ligase
Comments :This enzyme complex catalyzes the conversion of three molecules each of 2,3-dihydroxybenzoate and L-serine to form the siderophore enterobactin. In Escherichia coli the complex is formed by EntB (an aryl carrier protein that has to be activated by 4'-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyzes the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyzes the activation of L-serine by ATP, the condensation of the activated L-serine with the activated 2,3-dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule).

Created :EC 6.3.2.14 created 1972, modified 2012

BRENDA organisms :Escherichia coli

Swiss-ProtNo protein sequences are associated with EC 6.3.2.14 in Swiss-Prot

TrEMBLNo protein sequences are associated with EC 6.3.2.14 in TrEMBL

Click here to Report Sequence Evidence
for EC 6.3.2.14.

Links to other databases
NC-IUBMB, INTENZ, ENZYME, PDB, BRENDA, KEGG, BIOCYC, PubMed,NCBI-Entrez

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